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Lipid Oxidation

Lipid Oxidation PDF
Author: Edwin N. Frankel
Publisher: Elsevier
ISBN: 085709792X
Size: 52.91 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 488
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In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.

Lipid Oxidation Pathways Volume Two

Lipid Oxidation Pathways  Volume Two PDF
Author: Afaf Kamal-Eldin
Publisher: AOCS Publishing
ISBN: 9781893997561
Size: 61.13 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 324
View: 6346

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This volume complements Lipid Oxidation Pathways, Volume 1 by focusing on the oxidation kinetics and mechanisms governing the behavior of different molecular species involved in lipid oxidation reactions. It provides a more detailed review of the reactions of other lipid molecules than conventional polyunsaturated fatty acids.

Lipid Oxidation

Lipid Oxidation PDF
Author: Amy S. Logan
Publisher: Elsevier
ISBN: 0988856514
Size: 33.71 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 548
View: 7444

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Lipid oxidation in food systems is one of the most important factors which affect food quality, nutrition, safety, color and consumers’ acceptance. The control of lipid oxidation remains an ongoing challenge as most foods constitute very complex matrices. Lipids are mostly incorporated as emulsions, and chemical reactions occur at various interfaces throughout the food matrix. Recently, incorporation of healthy lipids into food systems to deliver the desired nutrients is becoming more popular in the food industry. Many food ingredients contain a vast array of components, many of them unknown or constituting diverse or undefined molecular structures making the need in the food industry to develop effective approaches to mitigate lipid oxidation in food systems. This book provides recent perspectives aimed at a better understanding of lipid oxidation mechanisms and strategies to improve the oxidative stability of food systems. Five chapters on naturally-derived antioxidants that focus on applications within food systems Contributors include an international group of leading researchers from academic, industrial, and governmental entities Discusses the oxidative stability of enzymatically produced oils and fats Provides overviews on the complexities of lipid oxidation mechanisms, and emulsion systems most suseptible to rapid lipid oxidation

Lipid Oxidation Products

Lipid Oxidation Products PDF
Author: Jean-François Rontani
Publisher: Cambridge Scholars Publishing
ISBN: 1527573591
Size: 32.98 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 190
View: 7083

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This book describes the photooxidation and autoxidation of the lipid components of phototrophic organisms. These two processes, which act intensively during the senescence of phototrophs, have been relatively neglected in the relevant literature. The text details the mechanisms involved in type-II photosensitized oxidation and free radical oxidation (autoxidation) of the main unsaturated lipids, with a close focus on the specificity of the oxidation products formed and their potential to serve as tracers of these processes. It then discusses the effects of temperature and solar irradiance on the efficiency of type-II photooxidation processes, and looks at the possibility of photooxidative damage transferring into non-phototrophic material. The book ends with a detailed description of potential interactions between biotic and abiotic degradation processes, which, although very complex, must absolutely be factored in when studying the fate of organic matter in the environment.

Advances In Nmr Spectroscopy For Lipid Oxidation Assessment

Advances in NMR Spectroscopy for Lipid Oxidation Assessment PDF
Author: Hong-Sik Hwang
Publisher: Springer
ISBN: 331954196X
Size: 14.60 MB
Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 59
View: 294

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This Brief provides a comprehensive overview of NMR spectroscopy, covering techniques such as 1H, 13C, and 31P NMR, which are reliable tools to determine lipid oxidation level, to identify oxidation products, and to elucidate oxidation mechanism. The Brief shows that 1H NMR spectroscopy continually demonstrates reliability, accuracy, convenience, and advantages over conventional analytical methods in determination of the level of oxidation of edible oil during frying and storage through monitoring changes in several proton signals of oil, including olefinic, bisallylic and allylic protons. This modern analytical method is shown within this text to be used to identify oxidation products, including primary oxidation products such as hydroperoxides and conjugated dienes and secondary products such as aldehydes, ketones, epoxides and their derivatives. By identifying intermediates and final oxidation products, many oxidation mechanisms could be elucidated. A relatively newer method, the text demonstrates that 13C NMR and 31P NMR spectroscopy can also provide additional information on the molecular structure of an oxidation product. Backgrounds, principles, and advantages over conventional methods, most recent advances, and future prospects of these methods are discussed. Advances in NMR Spectroscopy for Lipid Oxidation Assessment begins by covering the various mechanisms of lipid oxidation, including various methods to determine oxidation products. NMR spectroscopy is then covered, including its applications in foods. The next section focuses on 1H NMR Spectroscopy, including its use for assessment of lipid oxidation during oil storage and frying. The following section focuses on 13C NMR spectroscopy, including its use in determining and identifying oxidation products and mechanisms. A final section focuses on sup31“/p>

Lipid Oxidation In Health And Disease

Lipid Oxidation in Health and Disease PDF
Author: Corinne M. Spickett
Publisher: CRC Press
ISBN: 1482202867
Size: 53.69 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 440
View: 1627

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Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Flavor Chemistry Of Lipid Foods

Flavor Chemistry of Lipid Foods PDF
Author: David B. Min
Publisher: The American Oil Chemists Society
ISBN: 9780935315240
Size: 46.85 MB
Format: PDF, ePub, Mobi
Category : Technology & Engineering
Languages : en
Pages : 462
View: 6493

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Hne And Further Lipid Peroxidation Products

HNE and Further Lipid Peroxidation Products PDF
Author: Werner Siems
Publisher: IOS Press
ISBN: 9781586035860
Size: 28.13 MB
Format: PDF, ePub, Docs
Category : Health & Fitness
Languages : en
Pages : 320
View: 684

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Focuses on products of lipid peroxidation used as biomarkers of oxidative stress. This book covers the entire field of HNE research, including subjects as Cell Cycle and Proteolysis, LPO Products, Antioxidants and Detoxification, Neurodegeneration and Aging, Lipid Peroxidation, HNE and Gene Regulation, Clinical Applications and HNE, and more.

Lipid Peroxidation Research

Lipid Peroxidation Research PDF
Author: Mahmoud Ahmed Mansour
Publisher: BoD – Books on Demand
ISBN: 1839685476
Size: 57.35 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 128
View: 463

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Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases.

Lipid Peroxidation

Lipid Peroxidation PDF
Author: Angel Catala
Publisher: BoD – Books on Demand
ISBN: 953510716X
Size: 60.35 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 548
View: 3208

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The purpose of this book is to concentrate on recent developments on lipid peroxidation. The articles collected in this book are contributions by invited researchers with a long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with general background in many different biological sciences. This volume offers you up-to-date, expert reviews of the fast-moving field of Lipid Peroxidation. The book is divided in four mayor sections: 1-Lipid peroxidation: chemical mechanisms, antioxidants, biological implications; 2-Evaluation of lipid peroxidation processes; 3-Lipid peroxidation in vegetables, oils, plants and meats and 4-Lipid peroxidation in health and disease.

The Lipid Handbook With Cd Rom Third Edition

The Lipid Handbook with CD ROM  Third Edition PDF
Author: Frank D. Gunstone
Publisher: CRC Press
ISBN: 9781420009675
Size: 17.59 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 1472
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Extensively revised, reorganized, and expanded, the third edition of the industry standard, The Lipid Handbook reflects many of the changes in lipid science and technology that have occurred in the last decade. All chapters have been rewritten, many by new authors, to match the updated thinking and practice of modern lipid science and bring a fresh perspective to twenty years of tradition. Retaining the general structure of the previous editions, The Lipid Handbook with CD-ROM, Third Edition collates a wide range of information into a single volume. New contributions highlight the latest technologies utilized in today's lipid science such as chromatographic analysis and nuclear magnetic resonance spectroscopy. An entirely new chapter is devoted to non-food uses such as lipids as surfactants, cosmetics, and biofuels. Expanded sections illustrate a growing emphasis on lipid metabolism and the nutritional, medical, and agricultural aspects including human dietary requirements and disorders of lipid metabolism. The dictionary section is vastly expanded to cover chemical structure, physical properties, and references to thousands of lipid and lipid related molecules. The handbook now includes a CD-ROM that allows instant access to tabulated and referenced information and can be searched either as the full text or by structure or substructure. Drawing from the best minds in the field, The Lipid Handbook with CD-ROM, Third Edition presents the latest technological developments and the current and future directions and applications of lipid science to the next generation of researchers.

Einfluss Von Hopfen Extrakt Fraktionen Auf Die Lipid Oxidation Von Lebensmitteln

Einfluss von Hopfen Extrakt Fraktionen auf die Lipid Oxidation von Lebensmitteln PDF
Author: Andrej Ganske
Publisher:
ISBN:
Size: 22.11 MB
Format: PDF, Kindle
Category :
Languages : de
Pages :
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Ziel der vorliegenden Arbeit war es, den Einfluss von Hopfen-Extrakt-Fraktionen auf die Lipid Oxidation von Lebensmitteln zu prüfen. Auf Grundlage dieser Erkenntnisse sollte das antioxidative Potential von Hopfen-Extrakt-Fraktionen beurteilt werden. Zu diesem Zweck wurden umfangreiche chemische Analysen durchgeführt.ger

Membrane Lipid Oxidation

Membrane Lipid Oxidation PDF
Author: Carmen Vigo-Pelfrey
Publisher: CRC Press
ISBN:
Size: 49.68 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 224
View: 5105

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Volume 1 of this three volume set compiles the efforts of distinguished scientists and focuses on the formation of free radicals, toxic effects of lipoperoxides, biological antioxidant protection against lipid peroxidation damage, and pathological implications of lipid peroxidation. This review also includes topics of vitamin E deficiency, carbon tetrachloride and ethanol poisoning, radiation damage, hyperbaric effects, tumors, aging, diabetes, liver degeneration, DNA damage, lipoprotein modification and atherosclerosis, multiple sclerosis, angiopathy, Parkinson's disease, lupus, and many other degenerative diseases. It is an excellent resource for biological chemists, cell biologists, and all who are interested in the pharmaceutical sciences.

Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes

Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes PDF
Author: Angel Catalá
Publisher: Frontiers Media SA
ISBN: 2889450821
Size: 27.78 MB
Format: PDF
Category :
Languages : en
Pages :
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The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.

New Techniques And Applications In Lipid Analysis

New Techniques and Applications in Lipid Analysis PDF
Author: Richard E. McDonald
Publisher: The American Oil Chemists Society
ISBN: 9780935315806
Size: 11.31 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 401
View: 4918

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New Techniques and Applications in Lipid Analysis provides an informative and comprehensive reference book covering the latest and most important analytical topics in lipid chemistry. Researchers in biomedicine, food industry, food processing, product development, nutrition and dietetics, oil processing, fat substitutes, and lipid technology, as well as students in the fields of food science and nutrition, will greatly benefit from this book.

Advances In Planar Lipid Bilayers And Liposomes

Advances in Planar Lipid Bilayers and Liposomes PDF
Author: A. Leitmannova Liu
Publisher: Elsevier
ISBN: 9780080462004
Size: 59.32 MB
Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 336
View: 3056

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The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series. This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications * Authoritative timely reviews by experts in this field * Indispensable source of information for new scientists

Advances In Lipid Methodology

Advances in Lipid Methodology PDF
Author: R O Adlof
Publisher: Elsevier
ISBN: 0857097946
Size: 76.60 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 386
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The fifth volume in the Advances in lipid methodology series is the first with new editor, Richard O. Adlof, but its objectives are still those of the previous editor, William W. Christie: ‘To provide readable, up-to-date reviews of rapidly expanding areas of lipid analysis and practical examples which should be of immediate use to lipid analysts’. As in the previous volumes of Advances in lipid methodology, the editor has chosen leading international experts to write individual chapters. Volume 5 contains four chapters on specific methodologies of lipid analysis and three which describe specific applications or standardization of methods. The methodologies are different scanning calorimetry for the study of physical properties of fats and oils; silver ion chromatography; atmospheric-pressure chemical-ionization mass spectrometry (APCI-MS); and supercritical fluid chromatography (SFC). Chapters on specific applications cover the analysis of genetically modified oils and the use of fatty acid profiling in the characterization of metabolic diseases. A further chapter provides an overview of the official standard methods used for fats and oils analysis and gives extensive listings of information on standards organizations.

Lipid Oxidation In Seafood

Lipid Oxidation in Seafood PDF
Author: Sajid Maqsood
Publisher: LAP Lambert Academic Publishing
ISBN: 9783844334616
Size: 69.81 MB
Format: PDF, Kindle
Category :
Languages : en
Pages : 88
View: 6139

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Lipid oxidation is one of the key problems associated with the loss of quality of seafood. In the seafood industry, lipid oxidation is a serious problem, not only because it produce rancid odors and flavors, decreases shelf life and alter texture and appearance of foods, but also because it can decrease the nutritional quality and safety of seafood. It is the process by which oxygen reacts with unsaturated lipids present in the foodstuff. In the presence of an initiator, polyunsaturated fatty acids can become oxidized and form alkyl radicals. When exposed to oxygen, the alkyl radicals rapidly form peroxyl radicals and these radicals can react with more lipids to produce hydroperoxides. As a lipid hydroperoxide decomposes, it forms numerous volatile compounds such as hexanal and propanal, which impact the sensory quality of foods. Lipid oxidation in seafood can be mediated by enzymes like lipoxygenase, cycloxygenase and haem protein like haemoglobin and myoglobin. Oxidation of lipids is accentuated in the immediate post-slaughter period, during handling, processing, storage and cooking. This process leads to discoloration, off-odor and off-flavor development.

Growth Hormone Related Diseases And Therapy

Growth Hormone Related Diseases and Therapy PDF
Author: Ken Ho
Publisher: Springer Science & Business Media
ISBN: 9781607613176
Size: 39.37 MB
Format: PDF
Category : Medical
Languages : en
Pages : 414
View: 1295

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The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.